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Image Search Results
Journal: PLoS ONE
Article Title: Long-Term Effects of (–)-Epigallocatechin Gallate (EGCG) on Pristane-Induced Arthritis (PIA) in Female Dark Agouti Rats
doi: 10.1371/journal.pone.0152518
Figure Lengend Snippet: For each animal the geometric mean of the APF-dependent fluorescence intensity distribution was determined as a sign for the HOCl-producing MPO activity of the blood neutrophils. (A): While in the healthy control group (n = 5) relatively stable values for the MPO activity were found throughout the experiment in the saline-treated positive control (n = 14), a strong increase in the HOCl production especially in the acute and in the chronic disease phase was detected. In the group with early MTX treatment (n = 15) the therapeutic effect of the drug was nicely reflected by considerably lower MPO activity values. (B): As the application of EGCG only reduced the arthritic symptoms upon early oral administration (n = 10), in this group also a strong reduction of the MPO activity values was observed. In the other EGCG treatment groups the HOCl production recurrently exceeded the range of normal MPO activity determined on d0 (dashed lines). Yet the differences were never statistically significant.
Article Snippet:
Techniques: Fluorescence, Activity Assay, Control, Saline, Positive Control